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Read morePatented a peptide that allows faster internalization of drugs within cells and the design of more effective therapeutic nanoconjugates
The membrane of a cell is an effective barrier that makes it difficult to deliver molecules, such as therapeutic compounds, in a targeted manner. In recent years, various strategies have been developed to get the molecules inside the cell, but in...
Read morePolymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo.
Andrade F, Rafael D, Vilar-Hernandez M, Montero S, Martinez-Trucharte F, Seras-Franzoso J, Diaz-Riascos ZV, Boullosa A, Garcia-Aranda N, Camara-Sanchez P, Arango D, Nestor M, Abasolo I, Sarmento B, Schwartz S Jr J Control Release. 2021 Jan 19...
Read moreNanotechnology‐based approaches for treating lysosomal storage disorders, a focus on Fabry disease
Abasolo I, Seras-Franzoso J, Molto-Abad M, Diaz-Riascos V, Corchero JL, Pintos-Morell G, Schwartz S Jr Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Dec 13:e1684. doi: 10.1002/wnan.1684. Abstract Lysosomal storage disorders (LSDs) are a...
Read morePerspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics
Anna Ulldemolins, Joaquin Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo, Petra Gener, Simo Schwartz Jr Cancer Drug Resist 2020;3:[Online First] Review ...
Read moreThe potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles
Petra Gener , Patricia Gonzalez Callejo, Joaquín Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo & Simo Schwartz. The presence of highly resistant cancer stem cells (CSCs) within tumors as drivers of metastatic spread has been...
Read moreExtracellular Vesicles as Drug Delivery Systems in Cancer
Laia Hernandez-Oller 1 , Joaquin Seras-Franzoso 1, Fernanda Andrade 1,2, Diana Rafael 1,2, Ibane Abasolo 1,2 , Petra Gener 1,2,* and Simo Schwartz Jr. 1,2,* 1 Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre...
Read moreNovel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs
Andreia Almeida 1, Marco Araújo 2, Ramon Novoa-Carballal 3, Fernanda Andrade 4, Hugo Gonçalves 5, Rui L Reis 3, Marlene Lúcio 6, Simó Schwartz Jr 7, Bruno Sarmento 8 PMID: 32409071 DOI: 10.1016/j.msec.2020.110920 Abstract Chitosan was grafted...
Read moreSimvastatin-loaded polymeric micelles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease
Diana Hide 1, Mar Gil 2, Fernanda Andrade 3, Diana Rafael 4, Imma Raurell 5, Miren Bravo 6, Aurora Barberá 7, Jordi Gracia-Sancho 8, Víctor Vargas 9, Salvador Augustin 10, Joan Genescà 11, Simo Schwartz Jr 12, Maria Martell 13 PMID: 32681987 DOI...
Read moreThree researchers at VHIR receive a grant from the Spanish Association Against Cancer
The Spanish Association Against Cancer (AECC) presented today, within the framework of World Cancer Research Day, the resolution of the grants to promote research against cancer. Among the selected candidates, there are three researchers working...
Read moreCerium oxide nanoparticles may improve hepatocellular carcinoma prognosis
Hepatocellular carcinoma is the most common liver cancer and ranks third in the world in terms of mortality. Its appearance is related to the hepatitis B and C viruses, alcoholism, metabolic diseases of the liver and exposure to certain toxins...
Read moreIntracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells
Montero S, Seras-Franzoso J, Andrade F, Martinez-Trucharte F, Vilar-Hernández M, Quesada M, Xandri H, Arango D, Abasolo I, Rafael D, Schwartz S Jr. Pharmaceutics. 2020 Feb 21;12(2). pii: E185. doi: 10.3390/pharmaceutics12020185...
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