Kidney Physiopathology

Kidney Physiopathology

We are an interdisciplinary group of basic scientists and physicians devoted to the study of pathogenic mechanisms of renal diseases including inherited rare tubulopathies, tubular injury-regeneration processes and cancer, interstitial fibrosis in chronic kidney disease, and focal segmental glomerulosclerosis. Our aim is to discover novel diagnostic and prognostic biomarkers, as well as therapeutic targets to develop new solutions for diseases that are currently with no treatment.

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Kidney Physiopathology

Fig 1. Tubulo-interstitial fibrosis

Kidney Physiopathology

Fig 2. Scanningelectronmicroscopy of vascular corrosioncasts in control and KAP Tgmice (Circulation. 2009;119(14):1908-17).

Kidney Physiopathology

Fig 3. Proposed pathway diagram for HAVCR/KIM-1 action in ccRCC tumors (Cancer Research. 2014;74(5):1416-28)

Kidney Physiopathology

Fig 4. Kaplan-Meierestimates of 100 monthsoverall High Risk (right panel) according to pSTAT-3 S727 levels. Metastaticpatientshavebeenexcluded. Cancer Research. 2014;74(5):1416-28

Kidney Physiopathology

Fig 5. TranscriptomicAnalysisWith Mouse AffymetrixMicroarrays in kidneys of KAP Tgmice (Circulation. 2009;119(14):1908-17).