Novel methodology for labelling mesoporous silica nanoparticles using the 18F isotope and their in vivo biodistribution by positron emission tomography

Santiago Rojas Codina; Juan Domingo Gispert; Cristina Menchón; Herme G Baldoví; Mireia Buaki-Sogo; Milagros Rocha; Sergio Abad; Victor Manuel Victor; Hermenegildo Garcia; José Raúl Herance

 

Journal of Nanoparticle Research, , 17:131

http://link.springer.com/article/10.1007%2Fs11051-015-2938-0

Abstract

Nanoparticles have been proposed for several biomedical applications due to their potential as drug carriers, diagnostic and therapeutic agents. However, only a few of them have been approved for their use in humans. In order to gauge the potential applicability of a specific type of nanoparticle, in vivo biodistribution studies to characterize their pharmacokinetic properties are essential. In this regard, mesoporous silica nanoparticles (30–130 nm) have been functionalized with amino groups in order to react with N-succinimidyl 4-[18F]fluorobenzoate and thus anchor the 18F positron emission isotope by using a novel and easy labelling strategy. In vivo biodistribution was characterized in mice after intravenous administration of radiolabelled nanoparticles by positron emission tomography. Our results indicated that radiolabelled mesoporous silica nanoparticles were excreted into bile and urine and accumulated mainly in the organs of the reticuloendothelial system and lungs.