Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress.

Menchón C, Martín R, Apostolova N, Victor VM, Alvaro M, Herance JR, García H.
Small. 2012 Jun 25;8(12):1895-903.

Abstract

Ceriasupported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO(2) shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO(2) against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO(2) exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO(2) carrier. Overall the result presented here shows the potential of implementing well-established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology.

Intracellular Oxidative Stress. SMALL. 8 – 12, pp. 1895 – 1903. 06/2012