Objectives

• Diagnosis and study of critical cellular mechanisms in the pathogenesis of lysosomal storage diseases.
• Involvement of oxidative stress in the pathophysiology and evolution of type 1 diabetes mellitus, gestational diabetes and metabolic syndrome in children. Molecular mechanisms of cellular toxicity of oxidative hyperglycaemia and toxic dyslipidaemia.
• Study of pathogenic mechanisms and cellular stress response in pre-eclampsia, congenital heart defects and intrauterine growth restriction. Identification of maternal risk factors for these diseases.
• In vitro study of pathogenic mechanisms of endothelial and neuronal damage in cerebral ischaemia: relationship with in vivo oxidative processes in acute stroke patients.

Research lines

• Role of angiogenic factors in fetal heart development: congenital heart disease and fetal programming.Study of early markers of endothelial damage, cardiac dysfunction and angiogenesis regulation in pregnancy.
  Carmen Domínguez Luengo, Elisa Llurba Olivé, Olga Sánchez García, María Goya
• Diagnostic and disease progression biomarkers in lysosomal storage diseases, ischaemic stroke and multiple sclerosis.
  Mª Carmen Domínguez Luengo, Víctor Rodríguez Sureda, Ángel Vilches García
• Study of new therapeutic options in some lysosomal storage diseases: substrate reduction therapy, enzyme replacement therapy and chaperone enzyme activation.
  Mª Carmen Domínguez Luengo, Víctor Rodríguez Sureda , Olga Sánchez García, Pilar Martín Gallán