Publications

Rafael D, Merce Roca Melendres, Andrade F, Montero S, Martinez-Trucharte F, Vilar-Hernandez M, Francisco Duran-Lara, Schwartz S Jr, Abasolo I Int J Pharm. 2021 Jul 28:120954. doi: 10.1016/j.ijpharm.2021.120954. https://www.sciencedirect.com/science/article/abs/pii/S0378517321007602?via%3Dihub Abstract Despite the enormous efforts done by the scientific community in the last decades, advanced cancer is still considered an incurable disease. New formulations are continuously

Marwa M Abu-Serie, Fernanda Andrade, Patrícia Camára-Sánchez, Joaquin Seras-Franzoso, Diana Rafael, Zamira V Diaz-Riascos, Petra Gener, Ibane Abasolo, Simó Schwartz Jr. Nanomedicine (Lond.) (Epub ahead of print) https://www.futuremedicine.com/doi/abs/10.2217/nnm-2021-0013?journalCode=nnm Abstract Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic®

Sandra Claveau , Marek Kindermann , Alexandre Papine , Zamira V Díaz-Riascos,  Xavier Délen, Patrick Georges , Roser López-Alemany , Òscar Martínez Tirado , Jean-Rémi Bertrand , Ibane Abasolo , Petr Cigler , François Treussart Nanoscale.  2021 May 13. doi: 10.1039/d1nr00146a https://pubmed.ncbi.nlm.nih.gov/33982741/ Abstract Diamond nanoparticles (nanodiamonds) can transport active drugs in cultured cells as well as in vivo. However, in the latter case, methods

  Josep Merlo-Mas, Judit Tomsen Melero, Jose Luis Corchero, Elisabet González Mira, Albert Font, Jannik N.Pedersen, Natalia Garcia Aranda, Edgar Cristóbal-Lecina, Marta Alcaina-Hernando,  Rosa Mendoza, Elena García Fruitós, Teresa Lizárraga,  Susanne Resch, Christa Schimpel, Andreas Falk, Daniel Pulido, Miriam Royo, Simó Schwartz Jr,  Ibane Abasolo, Jan Skov Pedersen, Dganit Danino, Andreu Soldevila, Jaume Veciana, Santi Sala, Nora Ventosa, Alba Córdoba  The Journal of Supercritical Fluids.  Volume 173, July 2021, 105204

Seras-Franzoso J, Diaz-Riascos ZV, Corchero JL, Gonzalez P, Garcia-Aranda N, Mandana M, Riera R, Boullosa A, Mancilla S, Grayston A, Molto-Abad M, Garcia-Fruitos E, Mendoza R, Pintos-Morell G, Albertazzi L, Rosell A, Casas J, Villaverde A, Schwartz S Jr, Abasolo I. J Extracell Vesicles. 2021 Mar;10(5):e12058. doi: 10.1002/jev2.12058 https://pubmed.ncbi.nlm.nih.gov/33738082/ Abstract In the present study the

Eva Espinosa-Cano, Miguel Huerta-Madroñala, Patricia Cámara-Sánchez, Joaquin Seras-Franzoso, Simo Schwartz, Ibane Abasolo, Julio San Román, Maria Rosa Aguilar Materials Science & Engineering C.  Available online 10 March 2021, 112024   https://www.sciencedirect.com/science/article/abs/pii/S0928493121001636?via%3Dihub Abstract Cytotoxic chemotherapy continues to be the main therapeutic option for patients with metastatic breast cancer. Several studies have reported a significant association between

Andrade F, Roca-Melendres MM, Duran-Lara EF, Rafael D, Schwartz S Jr Cancers (Basel). 2021 Mar 9;13(5). pii: cancers13051164. doi: 10.3390/cancers13051164. https://pubmed.ncbi.nlm.nih.gov/33803133/ Abstract Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to

Tomsen-Melero J, Passemard S, Garcia-Aranda N, Diaz-Riascos ZV, Gonzalez-Rioja R, Nedergaard Pedersen , Lyngso J, Merlo-Mas J, Cristobal-Lecina E, Corchero JL, Pulido D, Camara-Sanchez P, Portnaya I, Ionita I, Schwartz S Jr, Veciana J, Sala S, Royo M, Cordoba A, Danino D, Pedersen JS, Gonzalez-Mira E, Abasolo I, Ventosa N ACS Appl Mater Interfaces. 2021

Andrade F, Rafael D, Vilar-Hernandez M, Montero S, Martinez-Trucharte F, Seras-Franzoso J, Diaz-Riascos ZV, Boullosa A, Garcia-Aranda N, Camara-Sanchez P, Arango D, Nestor M, Abasolo I, Sarmento B, Schwartz S Jr J Control Release. 2021 Jan 19. pii: S0168-3659(21)00031-6. doi: 10.1016/j.jconrel.2021.01.022. http://0.1016/j.jconrel.2021.01.022 Abstract Colorectal cancer (CRC) is a highly prevalent disease worldwide. Patient survival is

Abasolo I, Seras-Franzoso J, Molto-Abad M, Diaz-Riascos V, Corchero JL, Pintos-Morell G, Schwartz S Jr Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Dec 13:e1684. doi: 10.1002/wnan.1684. Abstract Lysosomal storage disorders (LSDs) are a group of rare diseases in which the defect of a lysosomal protein results in a pathogenic accumulation of nonmetabolized products within the cells.

Anna Ulldemolins, Joaquin Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo, Petra Gener, Simo Schwartz Jr Cancer Drug Resist 2020;3:[Online First]  Review  https://oaepublishstorage.blob.core.windows.net/ca7d21e9-ecf9-4748-aa88-c5c0536aa4f7/3786.pdf Abstract Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of chemoresistance. Even though considerable treatment progress and more effective therapies have been

Petra Gener , Patricia Gonzalez Callejo, Joaquín Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo & Simo Schwartz. The presence of highly resistant cancer stem cells (CSCs) within tumors as drivers of metastatic spread has been commonly accepted. Nonetheless, the likelihood of its dynamic phenotype has been strongly discussed. Importantly, intratumoral cell-to-cell communication seems to act

Laia Hernandez-Oller 1 , Joaquin Seras-Franzoso 1, Fernanda Andrade 1,2, Diana Rafael 1,2, Ibane Abasolo 1,2 , Petra Gener 1,2,* and Simo Schwartz Jr. 1,2,* 1 Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain; laia.hernandez@alumni.vhir.org (L.H.-O.); joaquin.seras@vhir.org

Andreia Almeida 1, Marco Araújo 2, Ramon Novoa-Carballal 3, Fernanda Andrade 4, Hugo Gonçalves 5, Rui L Reis 3, Marlene Lúcio 6, Simó Schwartz Jr 7, Bruno Sarmento 8 PMID: 32409071 DOI: 10.1016/j.msec.2020.110920 Abstract Chitosan was grafted with O-methyl-O’-succinylpolyethylene glycol and oleic acid after a two-step carbodiimide coupling. The structural and physicochemical characterization of the

Diana Hide 1, Mar Gil 2, Fernanda Andrade 3, Diana Rafael 4, Imma Raurell 5, Miren Bravo 6, Aurora Barberá 7, Jordi Gracia-Sancho 8, Víctor Vargas 9, Salvador Augustin 10, Joan Genescà 11, Simo Schwartz Jr 12, Maria Martell 13 PMID: 32681987 DOI: 10.1016/j.nano.2020.102267 Abstract Chronic liver disease (CLD) has no effective treatments apart from

Montero S, Seras-Franzoso J, Andrade F, Martinez-Trucharte F, Vilar-Hernández M, Quesada M, Xandri H, Arango D, Abasolo I, Rafael D, Schwartz S Jr. Pharmaceutics. 2020 Feb 21;12(2). pii: E185. doi: 10.3390/pharmaceutics12020185. https://www.ncbi.nlm.nih.gov/pubmed/?term=32098204 Abstract Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process

Gifre-Renom L, Seras-Franzoso J, Rafael D, Andrade F, Cano-Garrido O, Martinez-Trucharte F, Ugarte-Berzal E, Martens E, Boon L, Villaverde A, Opdenakker G, Schwartz S Jr, Arís A, Garcia-Fruitós E. Pharmaceutics. 2020 Feb 15;12(2). pii: E157. doi: 10.3390/pharmaceutics12020157. https://www.ncbi.nlm.nih.gov/pubmed/?term=32075316 Abstract Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have

O. Alonso,N. Franch,J. Canals,K. Arias-Alpízar,E. de la Serna,E. Baldrich,A. Diéguez Biosensors and Bioelectronics Volume 154, 15 April 2020, 112074 https://doi.org/10.1016/j.bios.2020.112074   Abstract A miniature internet of things (IoT)-based point-of-care testing (PoCT) fluorescence reader, able to perform both intensity and time-resolved measurements of different fluorescent tags, is presented. This low cost platform has been conceived for

Pesarrodona M, Sanchez-Garcia L, Seras-Franzoso J, Sanchez-Chardi A, Balta-Foix R, Camara-Sanchez P, Gener P, Jara JJ, Pulido D, Serna N, Schwartz S Jr, Royo M, Villaverde A, Abasolo I, Vazquez E ACS Appl Mater Interfaces. 2019 Dec 16. doi: 10.1021/acsami.9b15803. https://www.ncbi.nlm.nih.gov/pubmed/31840972?dopt=Abstract Abstract Five peptide ligands of four different cell surface receptors (nucleolin, CXCR1, CMKLR1, and

Gisela Ruiz-Vega, Kevin Arias-Alpízar , Erica de la Serna , Livia Neves Borgheti-Cardoso, Elena Sulleiro, Israel Molina, Xavier Fernandez-Busquets , Adrian Sanchez-Montalva, F. Javier del Campo, Eva Baldrich Biosensors and Bioelectronics.  Volume 150, 15 February 2020, 111925 https://www.sciencedirect.com/science/article/pii/S0956566319310048 Abstract Malaria, a parasitic infection caused by Plasmodium parasites and transmitted through the bite of infected female

Yaiza Montes-Cebrián , Albert Álvarez-Carulla , Gisela Ruiz-Vega, Jordi Colomer-Farrarons, Manel Puig-Vidal , Eva Baldrich  and Pere Ll. Miribel-Català Sensors 2019, 19, 5388   https://www.mdpi.com/1424-8220/19/24/5388 Abstract Considerable efforts are made to develop Point-of-Care (POC) diagnostic tests. POC devices have the potential to match or surpass conventional systems regarding time, accuracy, and cost, and they are significantly

Ruiz-Vega G, Garcia-Berrocoso T, Montaner J, Baldrich E Sensors and Actuators B: Chemical. 2019 Nov;298:126897. doi:10.1016/j.snb.2019.126897 https://doi.org/10.1016/j.snb.2019.126897 Abstract Using magnetic beads (MB) allows producing relatively fast and simple electrochemical magneto-immunosensors. However, this type of sensor implies carrying out serial MB incubation and washing steps in tubes using external magnets, a procedure that requires user training

Adaris M. L
opez-Marzo, Eva Baldrich Journal of Electroanalytical Chemistry. Volume 855, 15 December 2019, 113500 https://www.sciencedirect.com/science/article/pii/S1572665719307684 Abstract The use of nanoimmunoconjugates displaying multiple electroactive labels for enhanced analyte quantification is scarce in the literature. In this work, new nanoimmunoconjugates, based on gold nanoparticles (AuNPs) and either methylene blue (MB) or an NHS ester MB derivative

Gener Petra; Montero, Sara; Xandri-Monje, Helena; Diaz-Riascos, Zamira V; Rafael, Diana; Andrade, Fernanda; Martinez-Trucharte, Francesc; Gonzalez, Patricia; Seras-Franzoso, Joaquin; Manzano, Albert; Arango, Diego; Sayos, Joan; Abasolo, Ibane; Schwartz, Simo Jr Nanomedicine: Nanotechnology, Biology and Medicine Available online 27 October 2019, 102106 https://doi.org/10.1016/j.nano.2019.102106 Abstract Tumor recurrence, metastatic spread and progressive gain of chemo-resistance of advanced cancers

Matos AI, Carreira B, Peres C, Moura LIF, Conniot J, Fourniols T, Scomparin A, Martinez-Barriocanal, Arango D, Conde JP, Preat V, Satchi-Fainaro R, Florindo HF J Control Release. 2019 Aug 10;307:108-138. doi: 10.1016/j.jconrel.2019.06.017. https://doi.org/10.1016/j.jconrel.2019.06.017 Abstract Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide, constituting 6% of all cancers and the third

Pesarrodona M, Jauset T, Diaz-Riascos ZV, Sanchez-Chardi A, Beaulieu ME, Seras-Franzoso J, Sanchez-Garcia L, Balta-Foix R, Mancilla S, Fernandez Y, Rinas U, Schwartz S Jr, Soucek L, Villaverde A, Abasolo I, Vazquez E Advanced Science (Weinh). 2019 Jul 24;6(18):1900849. doi: 10.1002/advs.201900849. eCollection 2019 Sep 18. https://doi.org/10.1002/advs.201900849 Abstract Two structurally and functionally unrelated proteins, namely Omomyc

Gener P, Rafael D, Seras-Franzoso J, Perez A, Pindado LA, Casas G, Arango D, Fernandez Y, Diaz-Riascos ZV, Abasolo I, Schwartz S Jr. Cancers (Basel). 2019 Jul 26;11(8). pii: cancers11081058. doi: 10.3390/cancers11081058. https://doi.org/10.3390/cancers11081058   Abstract Therapeutic resistance seen in aggressive forms of breast cancer remains challenging for current treatments. More than half of the patients

Diana Rafael, Fernanda Andrade, Francesc Martinez-Trucharte, Jana Basas, Joaquín Seras-Franzoso , Marta Palau  Xavier Gomis, Marc Pérez-Burgos , Alberto Blanco, Alba López-Fernández, Roberto Vélez, Ibane Abasolo, Màrius Aguirre, Joan Gavaldà, and Simó Schwartz Jr. Nanomaterials 2019, 9, 380; doi:10.3390/nano9030380 https://www.mdpi.com/2079-4991/9/3/380 Abstract: Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high

Mendez O, Peg V, Salvans C, Pujals M, Fernandez Y, Abasolo I, Perez J, Matres A, Valeri M, Gregori J, Villarreal L, Schwartz S, Ramon Y Cajal S, Tabernero J, Cortes J, Arribas J, Villanueva J Clin Cancer Res. 2018 Aug 22. pii: 1078-0432.CCR-18-0517. doi: 10.1158/1078-0432.CCR-18-0517. PMID: 30135148 https://www.ncbi.nlm.nih.gov/pubmed/?term=30135148 Abstract PURPOSE: The study of the

Rafael D, Andrade F, Montero S, Gener P, Seras-Franzoso J, Martínez F, González P, Florindo H, Arango D, Sayós J, Abasolo I, Videira M, and Schwartz Jr. S. , Prec. Nanomed. 2018 July;1(2):86-105 DOI:10.29016/180629.1 https://precisionnanomedicine.com/article/12 Abstract The search for an ideal gene delivery system is a long and laborious process in which several factors from

Cacicedo ML, Islan GA, León IE, Álvarez VA, Chourpa I, Allard-Vannier E, García-Aranda N, Díaz-Riascos ZV, Fernández Y, Schwartz S Jr, Abasolo I, Castro GR Colloids and surfaces. B, Biointerfaces  Volumen: 170   Páginas: 596-608   Fecha de publicación: 2018-Jun-26 (Epub 2018 Jun 26) https://www.ncbi.nlm.nih.gov/pubmed/29975908?dopt=Abstract Abstract The use of hybrid materials, where a matrix sustains nanoparticles controlling the

Gisela Ruiz-Vega , Alicia García-Robaina, Manel Ben Ismail,  Helena Pasamar, Teresa García-Berrocoso, Joan Montaner, Mohammed Zourob, Ali Othmane, F. Javier del Campo, Eva Baldrich Biosensors and Bioelectronics Volume 115, 15 September 2018, Pages 45-52 https://doi.org/10.1016/j.bios.2018.05.020 Abstract Magnetic beads (MB) have been extensively used to produce sensitive and efficient electrochemical magneto-immunosensors. However, MB effective handling requires

Erica de la Serna, Elena Martínez-García,  Teresa García-Berrocoso, Anna Penalba, Antonio Gil-Moreno,  Eva Colas, Joan Montaner, Eva Baldrich Sensors and Actuators B: Chemical Volume 269, 15 September 2018, Pages 377-384 https://doi.org/10.1016/j.snb.2018.05.003 Abstract Immunoassays and immunosensors are extensively described diagnostic tools. However, they often entail time-consuming multi-step procedures that are difficult to perform outside centralized diagnostic

  Book – Nanoparticles in Life Sciences and Biomedicine The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several

Marzo AM, Hoyos-de-la-Torre R, Baldrich E. Anal Chem. 2018 Mar 20;90(6):4010-4018. doi: 10.1021/acs.analchem.7b05150. Epub 2018 Mar 9.López- https://www.ncbi.nlm.nih.gov/pubmed/29498271?dopt=Abstract Abstract Gold nanoparticles (AuNPs) have been exploited as signal-producing tags in electrochemical biosensors. However, the electrochemical detection of AuNPs is currently performed using corrosive acid solutions, which may raise health and environmental concerns. Here, oxidant salts, and

Diana Rafael, Francesc Martínez, Fernanda Andrade, Joaquim Seras-Franzoso, Natalia Garcia-Aranda, Pertra Gener, Joan sayós, Diego Arango, Ibane Abasolo, Simó Schwartz Jr. Chemical Engineering Journal https://www.sciencedirect.com/science/article/pii/S1385894717322374 Abstract New polymeric biomaterials and nanomedicines targeting cancer cells are highly required because of their potential clinical applications. Gene therapy enjoys high popularity as advanced therapy due to its high

Rocas P, Fernández Y, García-Aranda N, Foradada L, Calvo P, Avilés P, Guillén MJ, Schwartz S Jr., Rocas J, Albericio F, Abasolo I. Nanomedicine. 2018 Feb;14(2):257-267. doi: 10.1016/j.nano.2017.10.009. Epub 2017 Nov 7. https://www.ncbi.nlm.nih.gov/pubmed/?term=Improved+Pharmacokinetic+Profile+of+Lipophilic+Anti-Cancer+Drugs+Using+%CE%B1%CE%BD%CE%B23-targeted+Polyurethane-Polyurea+Nanoparticles  Abstract Glutathione degradable polyurethane-polyurea nanoparticles (PUUa NP) with a disulfide-rich multiwalled structure and a cyclic RGD peptide as a targeting moiety were

Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328. https://www.ncbi.nlm.nih.gov/pubmed/29176033 Abstract Cellular senescence is a cell fate program that entails essentially irreversible proliferative arrest in response to damage signals. Tumor necrosis factor-alpha (TNFα), an important pro-inflammatory cytokine secreted by some types of senescent cells,

Martínez-Barriocanal Á, Arcas-García A, Magallon-Lorenz M, Ejarque-Ortíz A, Negro-Demontel ML, Comas-Casellas E, Schwartz S Jr, Malhotra S, Montalban X, Peluffo H, Martín M, Comabella M, Sayós J. Scientific Reports, 2017 Oct 19;7(1):13544. https://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+Specific+Mutations+in+Cd300+Complexes+Formation%3B+Potential+Implication+of+Cd300f+in+Multiple+Sclerosis. Abstract Herein, we have used bioinformatics tools to predict five clusters defining ligand-binding sites on the extracellular domain of human CD300b receptor, presumably

Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grunweller A, Gu Z, Halas

G. Ruiz-Vega, E. Baldrich. Sensors and Actuators B: Chemical , 247, 718–726.   http://www.sciencedirect.com/science/article/pii/S092540051730494X Magnetic particles (MP) are extensively used to improve immunocapture and immunodetection. Com-pared to two-dimensional surfaces, MP provide wider active areas, efficient mixing with the sample,and target separation from other sample components. Nevertheless, MP handling is more tedious thanclassical techniques, such as

Mateo-Lozano S, Bazzocco S, Rodrigues P, Mazzolini R, Andretta E, Dopeso H, Fernandez Y, Del Llano E, Bilic J, Suarez-Lopez L, Macaya I, Carton-Garcia F, Nieto R, Jimenez-Flores LM, de Marcondes PG, Nunez Y, Afonso E, Cacci K, Hernandez-Losa J, Landolfi S, Abasolo I, Ramon Y Cajal S, Mariadason JM, Schwartz S Jr, Matsui T,

Andretta E, Carton-Garcia F, Martinez-Barriocanal, de Marcondes PG, Jimenez-Flores LM, Macaya I, Bazzocco S, Bilic J, Rodrigues P, Nieto R, Landolfi S, Ramon Y Cajal S, Schwartz S, Brown A, Dopeso H, Arango D Sci Rep. 2017 Feb 7;7:41576. https://www.ncbi.nlm.nih.gov/pubmed/28169277?dopt=Abstract Abstract EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing

Schwartz S Jr Nanomedicine (Lond). 2017 Feb;12(4):271-274. doi: 10.2217/nnm-2016-0390. Epub 2017 Jan 17. https://www.ncbi.nlm.nih.gov/pubmed/?term=28093937  

Codina SR, Herance JR, Centeno A, Valero J, Arias B, Miquel I, Sánchez P, Rincón E, López R, Murat J. J Burn Care Res. 2017 Jan 31. doi: 10.1097/BCR.0000000000000497 https://www.ncbi.nlm.nih.gov/pubmed/?term=28157787 Abstract Blood loss during grafting surgery represents a major concern of this procedure and the development of hemostatic agents for this indication is highly desirable.

Piella J, Bastús NG, Puntes V. Bioconjug Chem. 2017 Jan 18;28(1):88-97. doi: 10.1021/acs.bioconjchem.6b00575. Epub 2016 Dec 20. https://www.ncbi.nlm.nih.gov/pubmed/?term=27997136 Abstract Surface modifications of highly monodisperse citrate-stabilized gold nanoparticles (AuNPs) with sizes ranging from 3.5 to 150 nm after their exposure to cell culture media supplemented with fetal bovine serum were studied and characterized by the combined

Maroto A, Illescas T, Melendez M, Arevalo S, Rodo C, Peiro JL, Belfort M, Cuxart A, Carreras E J Matern Fetal Neonatal Med. 2017 Jan 16:1-5. doi: 10.1080/14767058.2016.1247262. https://www.ncbi.nlm.nih.gov/pubmed/27997256?dopt=Abstract   Abstract OBJECTIVE: To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses

Marset A, Begines P, López Ó, Maya I, García-Aranda N, Schwartz S Jr, Abasolo I, Fernández-Bolaños JG. Future Med Chem. 2016 Dec;8(18):2185-2195. Epub 2016 Nov 15. https://www.ncbi.nlm.nih.gov/pubmed/27845568 Abstract AIM: Numerous chronic diseases exhibit multifactorial etiologies, so focusing on a single therapeutic target is usually an inadequate treatment; instead, multi-target drugs are preferred. Herein, a panel

Ana Blas-Garcia, Herme G. Baldoví,  Miriam Polo,  Victor M. Victor,  Hermenegildo Garcia  and  Jose Raul Herance  RSC Advances, Issue 36, 2016, http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA27662D#!divAbstract   Abstract In the present work, two carbon quantum dots with onion ring morphology, C-NOR and C-NOR(Eu) with an average size of 40 nm differing in the absence or presence of Eu3+ as Lewis

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vazquez E, Schwartz S Jr, Abasolo I, Corchero JL, Mangues R, Villaverde A Sci Rep. 2016 Oct 24;6:35765. http://www.nature.com/articles/srep35765 Abstract In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others,

Giannotti, Marina; Abasolo, Ibane; Oliva, Mireia; Andrade, Fernanda; García-Aranda, Natalia; Melgarejo, Marta; Pulido, Daniel; Corchero, José; Fernández, Yolanda; Villaverde, Antonio; Royo, Miriam; Garcia-Parajo, Maria; Sanz, Fausto; Schwartz S Jr. ACS Applied Materials and Interfaces, 2016 Oct 5;8(39):25741-25752. https://www.ncbi.nlm.nih.gov/pubmed/27610822 Abstract Lysosomal storage disorders are currently treated by enzyme replacement therapy (ERT) through the direct administration of

Z Herrasti, F Martínez, E Baldrich (2016)  Sens Act B, 234:667–673 Sensors and Actuators B: Chemical Volume 234, 29 October 2016, Pages 667–673 http://dx.doi.org/10.1016/j.snb.2016.05.018 Abstract Nanomaterials such as carbon nanotubes (CNT) are extensively used to produce electrodes of enhanced performance. However, since their incorporation tends to be irreversible, nanostructured electrodes are used only once or

Li Y, Italiani P, Casals E, Valkenborg D, Mertens I, Baggerman G, Nelissen I, Puntes VF, Boraschi D. ACS Appl Mater Interfaces. 2016 , 8 (42), pp 28437–28447 https://www.ncbi.nlm.nih.gov/pubmed/?term=27670583 Abstract The possibility that nanomaterials could perturb the normal course of an inflammatory response is a key issue when assessing nanoimmunosafety. The alteration of the normal progress

Patarroyo J, Genç A, Arbiol J, Bastús NG, Puntes V. Chem Commun (Camb). 2016 Sep 21;52(73):10960-3. https://www.ncbi.nlm.nih.gov/pubmed/?term=27498830 Abstract Green silver nanorods (Ag NRs) of a low aspect ratio (2.8) have been produced in high yields via an optimized, simple, and robust one-pot polyol method in the presence of tannic acid, which favors the nucleation of

Rojas S, Herance JR, Gispert JD, Arias B, Miquel I, López R, Sánchez P, Rincón E, Murat J Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/?term=27550654   Abstract BACKGROUND AND OBJECTIVES: TT-173 is the first topical hemostatic agent based on tissue factor. To prevent thromboembolic events and intravascular coagulation it

Pesarrodona M1, Fernández Y, Foradada L, Sánchez-Chardi A, Conchillo-Solé O, Unzueta U, Xu Z, Roldán M, Villegas S, Ferrer-Miralles N, Schwartz S Jr, Rinas U, Daura X, Abasolo I, Vázquez E, Villaverde A. Biofabrication. 2016 Apr 14;8(2):025001 https://www.ncbi.nlm.nih.gov/pubmed/?term=Conformational+and+functional+variants+of+CD44-targeted+protein+nanoparticles+bio-produced+in+bacteria Abstract Biofabrication is attracting interest as a means to produce nanostructured functional materials because of its operational

I Cabrera, I Abasolo, JL.Corchero, E Elizondo, P Rivera Gil, E Moreno, J Faraudo, S Sala, D Bueno, E González-Mira, M Rivas, M Melgarejo, D Pulido, F Albericio, M Royo, A Villaverde, M F. García-Parajo, Schwartz S Jr., N Ventosa, J Veciana Advanced Healthcare Materials. 2016 Apr 6;5(7):829-40 https://www.ncbi.nlm.nih.gov/pubmed/?term=Alpha-Galactosidase+A+Loaded+Nanoliposomes+with+Enhanced+Enzymatic+Activity+and+Intracellular+Penetration. Abstract Lysosomal storage disorders (LSD) are

Rodríguez-Sureda V, Crovetto F, Triunfo S, Sánchez O, Crispi F, Llurba E, Gratacós E, Figueras F, Domínguez C. Biol Chem. 2016 Mar;397(3):269-79. https://www.ncbi.nlm.nih.gov/pubmed/?term=26756094 Abstract The pathogenic basis of abnormal placentation and dysfunction in preeclampsia (PE) is highly complex and incompletely understood. Secretory sphyngomyelinase activity (S-ASM) was analyzed in plasma samples from 158 pregnant women developing

Contreras-Muñoz P, Fernández-Martín A, Torrella R, Serres X, De la Varga M, Viscor G, Järvinen TA, Martínez-Ibáñez V, Peiró JL, Rodas G, Marotta M. Int J Sports Med. 2016 Mar;37(3):183-90. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+New+Surgical+Model+of+Skeletal+Muscle+Injuries+in+Rats+Reproduces+Human+Sports+Lesions. Abstract Skeletal muscle injuries are the most common sports-related injuries in sports medicine. In this work, we have generated a new surgically-induced skeletal muscle

E. Carreras, A. Maroto, T. Illescas, M. Meléndez, S. Arévalo, J. L. Peiró,C. G. García-Fontecha, M. Belfort, A. Cuxart ULTRASOUND OBST GYN Volume 47, Issue 2, February 2016 Pages 162–167 http://onlinelibrary.wiley.com/doi/10.1002/uog.15732/abstract;jsessionid=CFF3B04EE42373E15C7C000FDABCBD92.f04t02 ABSTRACT Objectives To report our preliminary experience in the use of prenatal ultrasound examination to assess lower-limb movements in fetuses with myelomeningocele. We aimed to

Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz S Jr, Videira MA. Int J Pharmatech 2016 Feb 4. pii: S0378-5173(16)30075-8. http://www.sciencedirect.com/science/article/pii/S0378517316300758 Abstract In past years, a considerable progress has been made in the conversion of conventional chemotherapy into potent and safe nanomedicines. The ultimate goal is to improve the therapeutic window of

Gener P, Rafael DF, Fernandez Y, Ortega JS, Arango D, Abasolo I, Videira M, Schwartz S Jr. Nanomedicine (Lond) 2016 Feb; 11(3):307-20 https://www.ncbi.nlm.nih.gov/pubmed/26785724 Abstract Despite the progress in cancer treatment over the past years advanced cancer is still an incurable disease. Special attention is pointed toward cancer stem cell (CSC)-targeted therapies, because this minor cell

N Uria, N Abramova, A Bratov, FX Muñoz-Pascual, E Baldrich Talanta,  Volume 147, 15 January 2016, Pages 364–369 http://www.sciencedirect.com/science/article/pii/S0039914015303775   Abstract It is well known that the metabolic activity of some microorganisms results in changes of pH of the culture medium, a phenomenon that can be used for detection and quantification of bacteria. However, conventional glass

Z Herrasti, E de la Serna, G Ruiz-Vega, E Baldrich Developing enhanced magneto-immunosensors based on low-cost screen-printed electrode devices. Reviews in Analytical Chemistry, (2016) 35: 53–85. Artículo de revisión invitado. https://www.researchgate.net/publication/304923361_Developing_enhanced_magnetoimmunosensors_based_on_low-cost_screen-printed_electrode_devices Abstract Electrochemical magnetoimmunosensors combine a number of issues that guarantee extremely high performance and also compatibility with the study of complex sample matrices. First,

Gener P, Gouveia LP, Sabat GR, de Sousa Rafael DF, Fort NB, Arranja A, Fernández Y, Prieto RM, Ortega JS, Arango D, Abasolo I, Videira M, Schwartz S Jr. Nanomedicine. 2015 Nov;11(8):1883-92. https://www.ncbi.nlm.nih.gov/pubmed/?term=Fluorescent+CSC+models+evidence+that+targeted+nanomedicines+improve+treatment+sensitivity+of+breast+and+colon+cancer+stem+cells. Abstract To be able to study the efficacy of targeted nanomedicines in marginal population of highly aggressive cancer stem cells (CSC), we

Andrade F, Neves Jd, Gener P, Schwartz S Jr, Ferreira D, Oliva M, Sarmento B.  Nanomedicine-NBM. 2015 Oct;11(7):1621-31 https://www.ncbi.nlm.nih.gov/pubmed/26049134 Abstract Pulmonary delivery of drugs for both local and systemic action has gained new attention over the last decades. In this work, different amphiphilic polymers (Soluplus®, Pluronic® F68, Pluronic® F108 and Pluronic® F127) were used to

Pizzi MN, Roque A, Fernández-Hidalgo N, Cuéllar-Calabria H, Ferreira-González I, Gonzàlez-Alujas MT, Oristrell G, Gracia-Sánchez L, González JJ, Rodríguez-Palomares J, Galiñanes M, Maisterra-Santos O, Garcia-Dorado D, Castell-Conesa J, Almirante B, Aguadé-Bruix S, Tornos P. Circulation. 2015 Sep 22;132(12):1113-26. https://www.ncbi.nlm.nih.gov/pubmed/?term=Improving+the+Diagnosis+of+Infective+Endocarditis+in+Prosthetic+Valves+and+Intracardiac+Devices+With+18F-Fluordeoxyglucose+Positron+Emission+Tomography%2FComputed+Tomography+Angiography%3A+Initial+Results+at+an+Infective+Endocarditis+Referral+Center. Abstract BACKGROUND: The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging

Nadezda Apostolova; Susana Rovira-Llopis; Herme G Baldoví; Sergio Navalon; Abdullah M. Asiri; Hermenegildo Garcia; José Raúl Herance. RSC Advances., 2015,5, 79423-79432 http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA12794G#!divAbstract Abstract Ceria nanoparticles with rhodamine B groups covalently attached on their surface (RhB-CeNPs) were successfully prepared to simultaneously exhibit antioxidant activity and the ability to detect oxidant species. In order to use them

Rodríguez-Carmona E, Mendoza R, Ruiz-Cánovas E, Ferrer-Miralles N, Abasolo I, Schwartz S Jr, Villaverde A, Corchero JL. Appl Microbiol Biotechnol. 2015 Sep;99(17):7079-88 https://www.ncbi.nlm.nih.gov/pubmed/?term=A+novel+bio-functional+material+based+on+mammalian+cell+aggresomes Abstract Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical and biotechnological interest, the

Pau Rocas, Yolanda Fernandez, Schwartz S Jr, Ibane Abasolo, Josep Rocas and Fernando Albericio   . Journal of Materials Chemistry B.  2015,3,  7604-7613 http://pubs.rsc.org/en/content/articlelanding/tb/2015/c5tb01345c#!divAbstract   Abstract Polyurethane–polyurea (PUUa) reactive prepolymers with adjusted hydrophobic and hydrophilic dangling chains to achieve multiwalled sub-30 nm nanoparticles are presented. The combination of an amphiphilic and a hydrophobic prepolymer at the

Z Herrasti, F Martínez, E Baldrich Lab on a Chip,  2015 Aug 21;15(16):3269-73 https://www.ncbi.nlm.nih.gov/pubmed/?term=Reversible+nanostructuration+of+microfluidic+electrode+devices+by+CNT+magnetic+co-entrapment Abstract Carbon nanotubes (CNTs) have been extensively used to produce electrodes of enhanced performance but have only been very recently exploited in microfluidic devices. In these cases, CNT electrodes had to be produced prior to device assembly, which might damage the CNT

Simó Schwartz Navarro Romero-Hernández LL, Merino-Montiel P, Montiel-Smith S, Meza-Reyes S, Vega-Báez JL, Abasolo I, Schwartz S Jr, López Ó, Fernández-Bolaños JG. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY   Pages : 99:67-81  Date : 2015-08 https://www.ncbi.nlm.nih.gov/pubmed/26046314   Abstract The stereoselective preparation of diosgenin-derived thio(seleno)ureas and glycomimetics bearing a 1,2,3-triazolyl tether on C-3 has been accomplished. The key

Bazzocco S, Dopeso H, Carton-Garcia F, Macaya I, Andretta E, Chionh F, Rodrigues P, Garrido M, Alazzouzi H, Nieto R, Sanchez A, Schwartz S Jr, Bilic J, Mariadason JM, Arango D. Clin Cancer Res. 2015 Aug 15;21(16):3695-704. https://www.ncbi.nlm.nih.gov/pubmed/25944804 Abstract PURPOSE: The clinical management of colorectal cancer patients has significantly improved because of the identification of

Baldoví HG, Herance JR, Manuel Víctor V, Alvaro M, Garcia H. Nanoscale. 2015 Aug 7;7(29):12484-91. doi: 10.1039/c5nr02903a. Epub 2015 Jul 2. https://www.ncbi.nlm.nih.gov/pubmed/?term=26135910 Abstract Thermal annealing at 400 °C of perylenetetracarboxylic anhydride in low molecular mass PEG gives rise to the formation of well defined nanoobjects of 2.5 nm height and size distribution from 10 to

Cartón-García F, Overeem AW, Nieto R, Bazzocco S, Dopeso H, Macaya I, Bilic J, Landolfi S, Hernandez-Losa J, Schwartz S Jr, Ramon y Cajal S, van Ijzendoorn SC, Arango D.  2015 Scientific Reports, Jul 23;5:12312 http://www.nature.com/articles/srep12312   Abstract: Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized

  J Moral-Vico, J Barallat, Ll Abad, R Olivé-Monllau, FX Muñoz-Pascual, A Galán Ortega, FJ del Campo, E Baldrich* Biosens Bioelectron, 2015 Jul 15;69:328-36 https://www.ncbi.nlm.nih.gov/pubmed/?term=Dual+chronoamperometric+detection+of+enzymatic+biomarkers+using+magnetic+beads+and+a+low-cost+flow+cell Abstract In this work we report on the production of a low cost microfluidic device for the multiplexed electrochemical detection of magneto bioassays. As a proof of concept, the device

Moshkovits I, Karo-Atar D, Itan M, Reichman H, Rozenberg P, Morgenstern-Ben-Baruch N, Shik D, Ejarque-Ortiz A, Hershko AY, Tian L, Coligan JE, Sayós J, Munitz A. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8708-13. https://www.ncbi.nlm.nih.gov/pubmed/?term=26124135 Abstract IL-4 receptor (R) α, the common receptor chain for IL-4 and IL-13, is a critical component in

Unzueta U, Vázquez F, Accardi G, Mendoza R, Toledo-Rubio V, Giuliani M, Sannino F, Parrilli E, Abasolo I, Schwartz S Jr, Tutino ML, Villaverde A, Corchero JL, Ferrer-Miralles N. Appl Microbiol Biotechnol. 2015 Jul;99(14):5863-7 https://www.ncbi.nlm.nih.gov/pubmed/?term=Strategies+for+the+production+of+difficult-to-express+full-length+eukaryotic+proteins+using+microbial+cell+factories%3A+production+of+human+alpha-galactosidase+A. Abstract Obtaining high levels of pure proteins remains the main bottleneck of many scientific and biotechnological studies. Among all the

Blasco-Lucas A, Reyes-Juárez JL, Nazarena Pizzi M, Permanyer E, Evangelista A, Galiñanes M. Ann Thorac Surg. 2015 Jun;99(6):2218-20. https://www.ncbi.nlm.nih.gov/pubmed/?term=Aortic+Arch+Mycotic+Aneurysm+Due+to+Scedosporium+Apiospermum+Reconstructed+With+Homografts Abstract A 39-year-old female, active parenteral drug user was diagnosed of spondylodiscitis. A computed tomography (CT) scan showed an extensive aortic arch aneurysm. A positron emission tomography (PET)-CT scan, showing significant aortic wall uptake of the

Ejarque-Ortiz A, Solà C, Martínez-Barriocanal Á, Schwartz S Jr, Martín M, Peluffo H, Sayós J. PLoS One. 2015 Apr 30;10(4):e0123928. doi: 10.1371/journal.pone.0123928. eCollection 2015. https://www.ncbi.nlm.nih.gov/pubmed/?term=The+Receptor+CMRF35-Like+Molecule-1+(CLM-1)+Enhances+the+Production+of+LPS-Induced+Pro-Inflammatory+Mediators+during+Microglial+Activation. Abstract CMRF35-like molecule-1 (CLM-1) belongs to a receptor family mainly expressed in myeloid cells that include activating and inhibitory receptors. CLM-1 contains two ITIMs and a single immunoreceptor tyrosine-based switch

Santiago Rojas Codina; Juan Domingo Gispert; Cristina Menchón; Herme G Baldoví; Mireia Buaki-Sogo; Milagros Rocha; Sergio Abad; Victor Manuel Victor; Hermenegildo Garcia; José Raúl Herance   Journal of Nanoparticle Research, March 2015, 17:131 http://link.springer.com/article/10.1007%2Fs11051-015-2938-0 Abstract Nanoparticles have been proposed for several biomedical applications due to their potential as drug carriers, diagnostic and therapeutic agents. However,

Mimmi MC, Ballico M, Amoroso F, Calcaterra V, Marotta M, Peiro JL, Pelizzo G. J Proteome Res. 2015 Mar 6;14(3):1465-71. https://www.ncbi.nlm.nih.gov/pubmed/?term=Phospholipid+profile+of+amniotic+fluid+in+ovine+model+of+congenital+diaphragmatic+hernia+(CDH)%3A+the+effect+of+fetal+tracheal+occlusion   Abstract Fetal endoscopic tracheal occlusion has been proposed as a prenatal intervention to ameliorate congenital diaphragmatic hernia (CDH) prognosis. Tracheal occlusion (TO) prevents pulmonary fluid egress, leading to tissue expansion, reversal of lung

Bueno J, Redecillas S, García L, Lara A, Giné C, Molino JA, Broto J, Segarra O. J Pediatr Surg. 2015 Mar;50(3):493-6. http://www.sciencedirect.com/science/article/pii/S0022346814007933 Abstract Although duodenal dilatation occurs in children with short bowel syndrome (SBS) facilitating dismotility and bacterial overgrowth, the duodenum has been an untouchable intestinal segment for lengthening procedures owing to its close relationship

Rodríguez-Sureda V, Vilches Á, Sánchez O, Audí L, Domínguez C. Oxid Med Cell Longev. 2015;2015:509241. https://www.ncbi.nlm.nih.gov/pubmed/?term=25852816 Abstract Down’s syndrome (DS) is characterized by a complex phenotype associated with chronic oxidative stress and mitochondrial dysfunction. Overexpression of genes on chromosome-21 is thought to underlie the pathogenesis of the major phenotypic features of DS, such as premature

Mascarenhas VV, Casaccia M, Fernandez-Martin A, Marotta M, Fontecha CG, Haddad S, Knörr J, Soldado F. J Orthop Res. 2014 Dec;32(12):1675-9. https://www.ncbi.nlm.nih.gov/pubmed/25124991 Abstract We assessed the role of subscapularis muscle denervation in the development of shoulder internal rotation contracture in neonatal brachial plexus injury. Seventeen newborn rats underwent selective denervation of the subscapular muscle. The

Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bilić J, Cartón-García F, Nieto R, Suárez-López L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, Cajal SR, Tabernero J, Tebbutt NC, Mariadason JM, Schwartz S Jr, Arango D. Nature Communications. 2014 Nov 21;5:5458 https://www.ncbi.nlm.nih.gov/pubmed/25413277 Abstract Activation of the small GTPase

Pelizzo G, Ballico M, Mimmi MC, Peiró JL, Marotta M, Federico C, Andreatta E, Nakib G, Sampaolesi M, Zambaiti E, Calcaterra V. Multidiscip Respir Med. 2014 Nov 4;9(1):54. https://www.ncbi.nlm.nih.gov/pubmed/?term=Metabolomic+profile+of+amniotic+fluid+to+evaluate+lung+maturity%3A+the+diaphragmatic+hernia+lamb+model. Abstract BACKGROUND: Tracheal occlusion (TO) stimulates lung growth in fetuses affected with congenital diaphragmatic hernia (CDH) although the processes involved in lung maturation still remain unknown.

Z Herrasti, F Martínez, E Baldrich Sensors and Actuators B: Chemical.  Volume 203, November 2014, Pages 891–898 http://www.sciencedirect.com/science/article/pii/S0925400514008399 Abstract Magnetic particles (MP) and carbon nanotubes (CNT) have been extensively exploited in biosensor development. It has been recently suggested that combining MP binding of electroactive molecules with CNT wiring of the MP surface could provide novel

Bustamante A, Dominguez C, Rodriguez-Sureda V, Vilches A, Penalba A, Giralt D, García-Berrocoso T, Llombart V, Flores A, Rubiera M, Molina C, Alvarez-Sabín J, Montaner J. Int J Stroke. 2014 Oct;9(7):910-6. doi: 10.1111/ijs.12160. Epub 2013 Oct 22. Abstract https://www.ncbi.nlm.nih.gov/pubmed/?term=24148838 BACKGROUND AND AIMS: Chitotriosidase, a component of innate immunity, constitutes a sensitive parameter of macrophage activation

Pesarrodona M, Ferrer-Miralles N; Ugutz Unzueta; Gener P; T Tatkiewivcs; Abasolo I; Ratera I; Veciana J;  Schwartz S Jr.; Villaverde A; Vazquez E. Int J Pharmatech. 2014 Oct 1;473(1-2):286-95 https://www.ncbi.nlm.nih.gov/pubmed/?term=Intracellular+targeting+of+CD44%2B+cells+with+self-assembling%2C+protein+only+nanoparticles. Abstract CD44 is a multifunctional cell surface protein involved in proliferation and differentiation, angiogenesis and signaling. The expression of CD44 is up-regulated in several types

Z Herrasti, F Martínez, E Baldrich Anal Bioanal Chem, 2014, 406: 5487–5493 https://link.springer.com/article/10.1007/s00216-014-7954-x Abstract In this work, chronoamperometric myelo-peroxidase (MPO) detection was accomplished using immunofunctionalized magnetic microparticles (MPs), disposable carbon screen-printed electrodes (C-SPEs), and a ready-to-use commercially available tetramethylbenzidine (TMB)-based enzymatic substrate. In order to reach the limit of detection (LOD) needed to study real

Soldado F, Fontecha CG, Marotta M, Benito D, Casaccia M, Mascarenhas VV, Zlotolow D, Kozin SH. J Shoulder Elbow Surg. 2014 Jul;23(7):1003-9. https://www.ncbi.nlm.nih.gov/pubmed/24388715 Abstract BACKGROUND: An internal rotation contracture of the shoulder is common after neonatal brachial plexus injuries due to subscapularis shortening and atrophy. It has been explained by 2 theories: muscle denervation and

Neus G. Bastús, Florind Merkoçi Jordi Piella, and Victor Puntes. Chem. Mater., 2014, 26 (9), pp 2836–2846.  DOI: 10.1021/cm500316k http://pubs.acs.org/doi/ipdf/10.1021/cm500316k Abstract Highly monodisperse sodium citrate-coated spherical silver nanoparticles (Ag NPs) with controlled sizes ranging from 10 to 200 nm have been synthesized by following a kinetically controlled seeded-growth approach via the reduction of silver nitrate

Candiota AP, Acosta M, Simões RV, Delgado-Goñi T, Lope-Piedrafita S, Irure A, Marradi M, Bomati-Miguel O, Miguel-Sancho N, Abasolo I, Schwartz S Jr, Santamaria J, Penadés S, Arús C. J Nanobiotechnology. 2014 Apr 5;12:12. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+new+ex+vivo+method+to+evaluate+the+performance+of+candidate+MRI+contrast+agents%3A+a+proof-of-concept+study. Abstract BACKGROUND: Magnetic resonance imaging (MRI) plays an important role in tumor detection/diagnosis. The use of exogenous contrast agents (CAs)

Neus G. Bastús, Florind Merkoçi, Jordi Piella, and Victor Puntes Chem. Mater., 2014, 26 (9), pp 2836–2846 http://pubs.acs.org/doi/abs/10.1021/cm500316k Abstract Highly monodisperse sodium citrate-coated spherical silver nanoparticles (Ag NPs) with controlled sizes ranging from 10 to 200 nm have been synthesized by following a kinetically controlled seeded-growth approach via the reduction of silver nitrate by the

Z Herrasti, R Olivé-Monllau, FX Muñoz-Pascual, F Martínez, E Baldrich Analyst. 2014 Mar 21;139(6):1334-9. https://www.ncbi.nlm.nih.gov/pubmed/?term=Electrochemical+biosensing+of+non-electroactive+targets+using+ferrocene-labeled+magnetic+particles+and+CNT+wiring Abstract We show that target binding onto ferrocene-modified magnetic microparticles (MP-Fc) promotes physical sheltering of the labels. This can be measured electrochemically by CNT wiring, which enhances ten-fold the signals registered compared to direct detection of the MPs alone. As

Cuadros T, Trilla E, Sarró E, Vilà MR, Vilardell J, de Torres I, Salcedo M, López-Hellin J, Sánchez A, Ramón y Cajal S, Itarte E, Morote J, Meseguer A. Cancer Res. 2014 Mar 1;74(5):1416-28. https://www.ncbi.nlm.nih.gov/pubmed/?term=HAVCR%2FKIM-1+activates+the+IL-6%2FSTAT-3+Pathway+in+ccRCC+and+Determines+Tumor+Progression+and+Patient+Outcome Abstract Renal cell carcinoma (RCC), the third most prevalent urological cancer, claims more than 100,000 lives/year worldwide. The clear cell

Llurba E, Sánchez O, Ferrer Q, Nicolaides KH, Ruíz A, Domínguez C, Sánchez-de-Toledo J, García-García B, Soro G, Arévalo S, Goya M, Suy A, Eur Heart J. 2014 Mar;35(11):701-7Pérez-Hoyos S, Alijotas-Reig J, Carreras E, Cabero L. https://www.ncbi.nlm.nih.gov/pubmed/?term=24159191 Abstract AIMS: Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were to ascertain

Llombart V, Dominguez C, Bustamante A, Rodriguez-Sureda V, Martín-Gallán P, Vilches A, García-Berrocoso T, Penalba A, Hernández-Guillamon M, Rubiera M, Ribó M, Eschenfelder C, Giralt D, Molina CA, Alvarez-Sabín J, Rosell A, Montaner J. Stroke. 2014 Feb;45(2):432-7. https://www.ncbi.nlm.nih.gov/pubmed/?term=24335228 Abstract BACKGROUND AND PURPOSE: Fluorescent molecular peroxidation products (FMPPs) are considered potential markers of molecular oxidative damage

P Rodríguez-Franco, Ll Abad, FX Muñoz-Pascual, M Moreno, E Baldrich Sens Act B, (2014) Volume 191, February 2014, Pages 634–642 http://dx.doi.org/10.1016/j.snb.2013.10.046 Abstract The properties of a transducer’s surface are crucial in biosensor development since they strongly condition the chemical routes applicable for bioreceptor incorporation and subsequent surface physical blocking. In this way, surface (bio)engineering should

Clau-Terré F, Sharma V, Cholley B, Gonzalez-Alujas T, Galiñanes M, Evangelista A, Fletcher N. Anesthesiology. 2014 Jan;120(1):32-41. https://www.ncbi.nlm.nih.gov/pubmed/?term=3.%09Can+simulation+help+to+answer+the+demand+for+echocardiography+education%3F Abstract There has been a recent explosion of education and training in echocardiography in the specialties of anesthesiology and critical care. These devices, by their impact on clinical management, are changing the way surgery is performed and

Peiro JL, Fontecha CG, Ruano R, Esteves M, Fonseca C, Marotta M, Haeri S, Belfort MA. Surg Endosc. 2013; 27(10):3835-40. https://www.ncbi.nlm.nih.gov/pubmed/23670742 Abstract BACKGROUND: This study aimed to assess the feasibility of single-access fetal endoscopy (SAFE) for the management of myelomeningocele (MMC) using intrauterine carbon dioxide as a distension medium in a sheep model. METHODS: This

Gomes-da-Silva LC, Fernández Y, Abasolo I, Schwartz S Jr, Ramalho JS, Pedroso de Lima MC, Simões S, Moreira JN. Nanomedicine (Lond). 2013 Sep;8(9):1397-413. http://www.futuremedicine.com/doi/abs/10.2217/nnm.12.174 Abstract AIM: The design of novel F3-targeted liposomes with adequate features for systemic administration, to enable efficient intracellular delivery of siRNA toward both cancer and endothelial cells from angiogenic blood vessels.

J Barallat, R Olivé-Monllau, J Gonzalo-Ruiz, R Ramírez-Satorras, FX Muñoz-Pascual, A Galán Ortega, E Baldrich Anal Chem, 2013, 85 (19), pp 9049–9056 http://pubs.acs.org/doi/abs/10.1021/ac401549d Abstract In this work, an amperometric immunosensor for detection of myeloperoxidase (MPO) in human plasma is reported. Detection is based on the immobilization of anti-MPO antibodies onto magnetic beads (MBs). Following MPO

Cabrera I, Elizondo E, Esteban O, Corchero JL, Melgarejo M, Pulido D, Cordoba A, Moreno E, Unzueta U, Vazquez E, Abasolo I, Schwartz S Jr, Villaverde A, Albericio F, Royo M, Garcia-Parajo MF, Ventosa N, Veciana J. Nano Lett. 2013 Aug 14;13(8):3766-74 http://pubs.acs.org/doi/abs/10.1021/nl4017072  

Herance JR, Gispert JD, Abad S, Victor VM, Pareto D, Torrent È, Rojas S. Contrast Media Mol Imaging.8 – 4, pp. 375 – 381. 01/07/2013 https://www.ncbi.nlm.nih.gov/pubmed/?term=Erythrocytes+labeled+with+%5B(18)+F%5DSFB+as+an+alternative+to+radioactive+CO+for+quantification+of Abstract Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and

Rodriguez-Berna, G ; Cabanas, MJD ; Mangas-Sanjuan, V ; Gonzalez-Alvarez, M ; Gonzalez-Alvarez, I ; Abasolo, I ; Schwartz S Jr ; Bermejo, M; Corma, A ACS Medicinal Chemistry Letters, Volume: 4  Issue: 7 Pages: 86-90.  May 28, 2013 http://pubs.acs.org/doi/abs/10.1021/ml400125z Abstract Despite that 9-substituted camptothecins are promising candidates in cancer therapy, the limited accessibility to this position

Cuadros T, Trilla E, Vilà MR, de Torres I, Vilardell J, Messaoud NB, Salcedo M, Sarró E, López-Hellin J, Blanco A, Mir C, Ramón y Cajal S, Itarte E, Morote J, Meseguer A. Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23. https://www.ncbi.nlm.nih.gov/pubmed/?term=Hepatitis+A+virus+cellular+receptor+1%2Fkidney+injury+molecule-1+is+a+susceptibility+gene+for+clear+cell+renal+cell+carcinoma+and+hepatitis+A+virus+cellular+receptor%2Fkidney+injury+molecule-1+ectodomain+shedding+a+predictive+biomarker+of+tumour+progression Abstract AIM OF THE STUDY: To correlate hepatitis A virus

Mazzolini R, Rodrigues P, Bazzocco S, Dopeso H, Ferreira AM, Mateo-Lozano S, Andretta E, Woerner SM, Alazzouzi H, Landolfi S, Hernandez-Losa J, Macaya I, Suzuki H, Cajal SR, Mooseker MS, Mariadason JM, Gebert J, Hofstra RM, Reventós J, Yamamoto H, Jr SS, Arango D. Int J Cancer. 2013 Apr 15;132(8):1790-9. https://www.ncbi.nlm.nih.gov/pubmed/23002058 Abstract Brush border Myosin

Corchero J.L., Gasser  B., Resina D., Smith W., Parrilli E., Vázquez F., Abasolo I., Giuliani M., Jäntti J., Ferrer P., Saloheimo M., Mattanovich D., Schwartz S. Jr, Tutino L., Villaverde A. Biotechnology Advances. 2013 Mar; 31(2):140-53. https://www.ncbi.nlm.nih.gov/pubmed/22985698 Abstract Both conventional and innovative biomedical approaches require cost-effective protein drugs with high therapeutic potency, improved bioavailability, biocompatibility,

Lopez-Hellin J, Cantarell C, Jimeno L, Sanchez-Fructuoso A, Puig-Gay N, Guirado L, Vilariño N, Gonzalez-Roncero FM, Mazuecos A, Lauzurica R, Burgos D, Plumed JS, Jacobs-Cacha C, Jimenez C, Fernandez A, Fernandez-Alvarez P, Torregrosa V, Nieto JL, Meseguer A, Alonso A; GREAT Study Group. Am J Transplant. 2013 Feb;13(2):493-500. doi: 10.1111/j.1600-6143.2012.04338.x. Epub 2012 Dec 3. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+form+of+apolipoprotein+A-I+is+found+specifically+in+relapses+of+focal+segmental+glomerulosclerosis+following+transplantation

E Prats-Alfonso, Ll Abad, N Casan-Pastor, J Gonzalo-Ruiz, E Baldrich Biosens Bioelectron. 2013 Jan 15;39(1):163-9 http://www.sciencedirect.com/science/article/pii/S0956566312004629 Abstract This work demonstrates the implementation of iridium oxide films (IROF) grown on silicon-based thin-film platinum microelectrodes, their utilization as a pH sensor, and their successful formatting into a urea pH sensor. In this context, Pt electrodes were fabricated

Khoo JP, Davies JE, Ang KL, Galiñanes M, Chin DT. Heart. 2013 Jan;99(1):41-7 https://www.ncbi.nlm.nih.gov/pubmed/?term=Differences+in+performance+of+five+types+of+aortic+valve+prostheses%3A+haemodynamic+assessment+by+dobutamine+stress+echocardiography. Abstract BACKGROUND: In patients being considered for aortic valve replacement, there remains controversy over which design or tissue offers the best performance. We aimed to evaluate in a single study the haemodynamic performances of five different widely used aortic valve prostheses:

Rojas S, Gispert JD, Abad S, Buaki-Sogo M, Victor VM, Garcia H, Herance JR. Mol Pharm. 2012 Dec 3;9(12):3543-50. doi: 10.1021/mp300382n. Epub 2012 Nov 20. https://www.ncbi.nlm.nih.gov/pubmed/?term=In+Vivo+Biodistribution+of+Amino-Functionalized+Ceria+Nanoparticles+in+Rats+Using Abstract A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the

Fernández-Hidalgo N1, Almirante B, Tornos P, González-Alujas MT, Planes AM, Galiñanes M, Pahissa A. Clin Microbiol Infect. 2012 Dec;18(12):E522-30. https://www.ncbi.nlm.nih.gov/pubmed/?term=5.%09Immediate+and+long-term+outcome+of+left-sided+infective+endocarditis.+A+12-year+prospective+study+from+a+contemporary+cohort+in+a+referral+hospital. Abstract The aim of this study was to describe the immediate and long-term prognosis of a contemporary cohort of patients with left-sided infective endocarditis (LSIE). A prospective observational cohort study was conducted in a referral

Menchón C, Martín R, Apostolova N, Victor VM, Alvaro M, Herance JR, García H. Small. 2012 Jun 25;8(12):1895-903. https://www.ncbi.nlm.nih.gov/pubmed/?term=Gold+Nanoparticles+Supported+on+Nanoparticulate+Ceria+as+a+Powerful+Agent+against Abstract Ceria–supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO(2) shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B

Abad S, Nolis P, Gispert JD, Spengler J, Albericio F, Rojas S, Herance JR. Chem Commun (Camb). 2012 Jun 21;48(49):6118-20 https://www.ncbi.nlm.nih.gov/pubmed/?term=Rapid+and+high-yielding+cysteine+labelling+of+peptides+with+N-succinimidyl Abstract Fast cysteine labelling of peptides promoted by an adjacent arginine has been observed with a standard labelling agent specific for amines, N-succinimidyl 4-[(18)F]fluorobenzoate.  

Tenbaum SP, Ordóñez-Morán P, Puig I, Chicote I, Arqués O, Landolfi S, Fernández Y, Herance JR, Gispert JD, Mendizabal L, Aguilar S, Cajal SR, Schwartz S Jr, Vivancos A, Espín E, Rojas S, Baselga J, Tabernero J, Muñoz A, Palmer HG. Nat Med.,  2012 Jun;18(6):892-901 https://www.ncbi.nlm.nih.gov/pubmed/22610277 Abstract The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central

Peluffo H, Alí-Ruiz D, Ejarque-Ortíz A, Heras-Alvarez V, Comas-Casellas E, Martínez-Barriocanal A, Kamaid A, Alvarez-Errico D, Negro ML, Lago N, Schwartz S Jr, Villaverde A, Sayós J. Brain Pathol. 2012 May;22(3):318-28. https://www.ncbi.nlm.nih.gov/pubmed/?term=Overexpression+of+the+immunoreceptor+CD300f+has+a+neuroprotective+role+in+a+model+of+acute+brain+injury. Abstract It is well known that cell surface immune receptors play a critical role in regulating immune and inflammatory processes in the central

Soldado F, Fontecha CG, Barber I, Velez R, Llusa M, Collado D, Rodriguez-Baeza A, Martinez-Ibañez V. J Pediatr Orthop. 2012 Apr-May;32(3):308-13. https://www.ncbi.nlm.nih.gov/pubmed/22411339 Abstract BACKGROUND: The periosteum in children has strong osteogenic power and is quite thick, facilitating procurement. However, it has been rarely used as a vascularized flap to enhance bone union in this age

Arango D, Al-Obaidi S, Williams DS, Dopeso H, Mazzolini R, Corner G, Byun DS, Carr AA, Murone C, Tögel L, Zeps N, Aaltonen LA, Iacopetta B, Mariadason JM. Am J Pathol. 2012 Apr;180(4):1509-21 https://www.ncbi.nlm.nih.gov/pubmed/22349300 Abstract Colorectal cancers (CRCs) are classified as having microsatellite instability (MSI) or chromosomal instability (CIN); herein termed microsatellite stable (MSS). MSI

Comas-Casellas E, Martínez-Barriocanal Á, Miró F, Ejarque-Ortiz A, Schwartz S Jr, Martín M, Sayós J. J Biol Chem. 2012 Mar 23;287(13):9682-93. https://www.ncbi.nlm.nih.gov/pubmed/?term=22291008   Abstract Herein we present the cloning and molecular characterization of CD300d, a member of the human CD300 family of immune receptors. CD300d cDNA was cloned from RNA obtained from human peripheral blood

Sánchez O, Llurba E, Marsal G, Domínguez C, Aulesa C, Sánchez-Durán MA, Goya MM, Alijotas-Reig J, Carreras E, Cabero L. Hum Reprod. 2012 Feb;27(2):358-65. https://www.ncbi.nlm.nih.gov/pubmed/?term=22116949 Abstract BACKGROUND: The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in

Mazzolini R, Dopeso H, Mateo-Lozano S, Chang W, Rodrigues P, Bazzocco S, Alazzouzi H, Landolfi S, Hernández-Losa J, Andretta E, Alhopuro P, Espín E, Armengol M, Tabernero J, Ramón Y Cajal S, Kloor M, Gebert J, Mariadason JM, Schwartz S Jr, Aaltonen LA, Mooseker MS, Arango D. Proc Natl Acad Sci U S A. 2012

Simon Guerrero; Jose Raul Herance; Santiago Rojas; Juan F. Mena; Juan Domingo Gispert; Gerardo A. Acosta; Fernando Albericio; Marcelo J. Kogan. BIOCONJUGATE CHEMISTRY. 23 -3, pp. 399 – 408. 03/2012. http://repositorio.uchile.cl/bitstream/handle/2250/121717/Guerrero_Simon.pdf;sequence=1 ABSTRACT Gold nanoparticles (AuNPs) have been extensively used in biological applications because of their biocompatibility, size, and ease of characterization, as well as an

Sarró E, Jacobs-Cachá C, Itarte E, Meseguer A. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):275-87. doi: 10.1016/j.taap.2011.11.007. Epub 2011 Dec 3. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+pharmacologically-based+array+to+identify+targets+of+cyclosporine+A-induced+toxicity+in+cultured+renal+proximal+tubule+cells   Abstract Mechanisms of cyclosporine A (CsA)-induced nephrotoxicity were generally thought to be hemodynamic in origin; however, there is now accumulating evidence of a direct tubular effect. Although genomic and proteomic experiments by our

Sánchez O, Rodríguez-Sureda V, Domínguez C, Fernández-Figueras T, Vilches A, Llurba E, Alijotas-Reig J. Immunobiology. 2012 Jan;217(1):44-53. doi: 10.1016/j.imbio.2011.08.003. Epub 2011 Aug 12. https://www.ncbi.nlm.nih.gov/pubmed/?term=21903293 Abstract Several soft-tissue dermal fillers have been reported to provoke immunogenicity and may cause adverse reactions despite claims regarding their safety. This study aimed to assess biomaterial-induced macrophage activation, cell-mediated immune

Casals E, Pfaller T, Duschl A, Oostingh GJ, Puntes VF. Small. 2011 Dec 16;7(24):3479-86. doi: 10.1002/smll.201101511. Epub 2011 Nov 7. https://www.ncbi.nlm.nih.gov/pubmed/?term=Hardening+of+the+nanoparticle%E2%80%93protein+corona+in+metal+(Au%2C+Ag)+and+oxide+(Fe3O4%2C+CoO%2C+and+CeO2)+nanoparticles   Abstract The surface modifications of metal and metal oxide nanoparticles with sizes ranging from 7 to 20 nm dispersed in commonly used cell culture medium supplemented with serum are investigated. All the tested

Botella P, Abasolo I, Fernández Y, Muniesa C, Miranda S, Quesada M, Ruiz J, Schwartz S Jr, Corma A. J Control Release. 2011 Dec 10;156(2):246-57 http://www.sciencedirect.com/science/article/pii/S0168365911004743 Abstract Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle

González E, Arbiol J, Puntes VF. Science. 2011 Dec 9;334(6061):1377-80 https://www.ncbi.nlm.nih.gov/pubmed/?term=Carving+at+the+nanoscale%3A+sequential+galvanic+exchange+and+Kirkendall+growth+at+room+temperature   Abstract Shape control of inorganic nanocrystals is important for understanding basic size- and shape-dependent scaling laws and is useful in a wide range of applications. With minor modifications in the chemical environment, it is possible to control the reaction and diffusion processes at

Herance R, Rojas S, Abad S, Jiménez X, Gispert JD, Millán O, Martín-García E, Burokas A, Serra MÀ, Maldonado R, Pareto D. Mol Imaging. 2011 Dec;10(6):481-7. https://www.ncbi.nlm.nih.gov/pubmed/22201539 Abstract In this study, we assessed the feasibility of using positron emission tomography (PET) and the tracer [¹¹C]OMAR ([¹¹C]JHU75528), an analogue of rimonabant, to study the brain cannabinoid

Martín-Gallán P, Carrascosa A, Gussinyé M, Domínguez C. J Cell Mol Med. 2007 Nov-Dec;11(6):1352-66. doi: 10.1111/j.1582-4934.2007.00068.x. https://www.ncbi.nlm.nih.gov/pubmed/?term=18205705 Abstract Oxidative stress has been implicated as a mechanism underlying hyperglycaemia-associated cellular damage and could play a role in the development of diabetes-related complications. This study aimed to evaluate the significance of changes in oxidant-antioxidant status in 176

Grande MT, Pascual G, Riolobos AS, Clemente-Lorenzo M, Bardaji B, Barreiro L, Tornavaca O, Meseguer A, López-Novoa JM. Free Radic Biol Med. 2011 Nov 15;51(10):1831-41. https://www.ncbi.nlm.nih.gov/pubmed/?term=Increased+oxidative+stress%2C+renin-angiotensin+system+and+sympathetic+overactivation+induce+hypertension+in+kidney+androgen-regulated+protein+transgenic+mice Abstract Gender differences in the incidence and severity of hypertension have suggested the involvement of a sex-dependent mechanism. Transgenic (Tg) mice overexpressing kidney androgen-regulated protein (KAP) specifically in kidney

E Baldrich, FX Muñoz Anal. Chem., 2011, 83 (24), pp 9244–9250 http://pubs.acs.org/doi/abs/10.1021/ac201137q Abstract Here, we combine the unique properties of carbon nanotubes (CNTs) and magnetic particles (MPs) to develop a novel biosensing approach for the specific detection of electroactive labels and targets. The assay is based on label/target capture and concentration using MPs. It follows

Tornavaca O, Sarró E, Pascual G, Bardaji B, Montero MA, Salcedo MT, Plana M, López-Hellin J, Itarte E, Meseguer A. PLoS One. 2011;6(9):e25746. doi: 10.1371/journal.pone.0025746. Epub 2011 Sep 28. https://www.ncbi.nlm.nih.gov/pubmed/?term=KAP+degradation+by+calpain+associates+with+CK2+phosphorylation+and+provides+a+novel+mechanism+for+Cyclosporine+A-induced+kidney+toxicity Abstract The use of cyclosporine A (CsA) is limited by its severe nephrotoxicity that includes reversible vasoconstrictor effects and proximal tubule cell injury, the latter

Ellison GM, Torella D, Dellegrottaglie S, Perez-Martinez C, Perez de Prado A, Vicinanza C, Purushothaman S, Galuppo V, Iaconetti C, Waring CD, Smith A, Torella M, Cuellas Ramon C, Gonzalo-Orden JM, Agosti V, Indolfi C, Galiñanes M, Fernandez-Vazquez F, Nadal-Ginard B. J Am Coll Cardiol. 2011 Aug 23;58(9):977-86. https://www.ncbi.nlm.nih.gov/pubmed/?term=Endogenous+cardiac+stem+cell+activation+by+insulin-like+growth+factor-1%2Fhepatocyte+growth+factor+intracoronary+injection+fosters+survival+and+regeneration+of+the+infarcted+pig+heart Abstract OBJECTIVES: The purpose of this

Rojas S, Gispert JD, Martín R, Abad S, Menchón C, Pareto D, Víctor VM, Alvaro M, García H, Herance JR. ACS Nano. 2011 Jul 26;5(7):5552-9. https://www.ncbi.nlm.nih.gov/pubmed/?term=Biodistribution+of+Amino-Functionalized+Diamond Abstract Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to confirm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed

Neus G. Bastús, Joan Comenge, and Víctor Puntes Langmuir, 2011, 27 (17), pp 11098–11105 http://pubs.acs.org/doi/abs/10.1021/la201938u Abstract Monodisperse citrate-stabilized gold nanoparticles with a uniform quasi-spherical shape of up to ∼200 nm and a narrow size distribution were synthesized following a kinetically controlled seeded growth strategy via the reduction of HAuCl4 by sodium citrate. The inhibition of

O Laczka, J del Campo, FX Muñoz-Pascual, E Baldrich Analytical Chemistry 83(11):4037-44 · June 2011 https://www.researchgate.net/publication/51053729_Electrochemical_Detection_of_Testosterone_by_Use_of_Three-Dimensional_Disc-Ring_Microelectrode_Sensing_Platforms_Application_to_Doping_Monitoring   Abstract Testosterone is one of the androgenic steroid hormones, the consumption of which is considered doping in most sports. Here, we present powerful 3D sensing platforms using novel disc-ring microelectrode array devices and exploit them for the competitive immunosensing of

Fontecha CG, Peiro JL, Sevilla JJ, Aguirre M, Soldado F, Fresno L, Fonseca C, Chacaltana A, Martinez V. Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):171-6. https://www.ncbi.nlm.nih.gov/pubmed/21353374 Abstract OBJECTIVE: Assess the feasibility of a fetoscopic patch coverage method for myelomeningocele repair in a sheep model. STUDY DESIGN: Experimental study. A myelomeningocele-like defect was created in

O Laczka, JM Maesa, N Godino, J del Campo, M Fougt-Hansen, JP Kutter, D Snakenborg, FX Muñoz-Pascual, E Baldrich Biosens Bioelectron. 2011 Apr 15;26(8):3633-40 https://www.ncbi.nlm.nih.gov/pubmed/21392960    

A García, R Espinosa, L Delgado, E Casals, E González, V Puntes, C Barata, X Font, A Sánchez Desalination, Volume 269, Issues 1–3, 15 March 2011, Pages 136–141 http://www.sciencedirect.com/science/article/pii/S0011916410007678 Abstract In this study, several standard toxicity tests have been performed on selected inorganic nanoparticles. Acute toxicity tests were selected according to their extensive use in toxicological

E Baldrich, R Gómez, G Gabriel, FX Muñoz Biosens Bioelectron. 2011 Jan 15;26(5):1876-82 https://www.ncbi.nlm.nih.gov/pubmed/20378329 Abstract Carbon nanotubes (CNT) have been exploited for an important number of electroanalytical and sensing purposes. Specifically, CNT incorporation to an electrode surface coating increases its roughness and area, provides electrocatalytic activity towards a variety of molecules, and improves electron transfer.

Davalos v, Dopeso H, Velho S, Monteiro Ferreira A, Cirnes L, Díaz-Chico N, Bilbao C, Ramírez R, Rodríguez G, Falcón O, León L, Niessen R, Keller G, Dallenbach-Hellweg G, Espín E, Armengol M, Perucho M, Imai K, Yamamoto H, Gebert JF, Díaz-Chico JC, Hofstra RM, Woerner SM, Seruca R, Schwartz Jr. S, Arango D. Oncogene. 2007

Martínez-Barriocanal A, Comas-Casellas E, Schwartz S Jr, Martín M, Sayós J. J Biol Chem. 2010 Dec 31;285(53):41781-94. https://www.ncbi.nlm.nih.gov/pubmed/?term=20959446 Abstract The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules of uncertain function presenting a negative charge within their transmembrane domain (CD300c, CD300d). In this paper,

Martín R, Menchón C, Apostolova N, Victor VM, Alvaro M, Herance JR, García H. ACS Nano. 2010 Nov 23;4(11):6957-65. https://www.ncbi.nlm.nih.gov/pubmed/?term=Gold+and+Platinum+on+Diamond+Nanoparticles+as+Antioxidant Abstract Diamond nanoparticles (DNPs) obtained by explosive detonation have become commercially available. These commercial DNPs can be treated under Fenton conditions (FeSO(4) and H(2)O(2) at acidic pH) to obtain purer DNP samples with a small

Suñé G, Sarró E, Puigmulé M, López-Hellín J, Zufferey M, Pertel T, Luban J, Meseguer A. PLoS One. 2010 Nov 10;5(11):e13930. https://www.ncbi.nlm.nih.gov/pubmed/?term=Cyclophilin+B+interacts+with+sodium-potassium+ATPase+and+is+required+for+pump+activity+in+proximal+tubule+cells+of+the+kidney   Abstract Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions are inhibited upon CsA binding. Albeit its great

Rivera Gil P, Oberdörster G, Elder A, Puntes V, Parak WJ. ACS Nano. 2010 Oct 26;4(10):5527-31. https://www.ncbi.nlm.nih.gov/pubmed/?term=Correlating+physico-chemical+with+toxicological+properties+of+nanoparticles%3A+the+present+and+the+future Abstract Nanotoxicology is still a new discipline. In this Perspective, both its origins and its future trends are discussed. In particular, we note several issues we consider important for publications in this field.

Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz S Jr, Esteller M. Cancer Cell. 2010 Oct 19;18(4):303-15. http://www.cell.com/cancer-cell/abstract/S1535-6108(10)00344-2 Abstract The global impairment of mature microRNAs (miRNAs) is emerging as a common feature of human tumors. One interesting scenario is that

O Laczka, C García-Aljaro, FJ del Campo, FX Muñoz, J Mas, E Baldrich Anal Chim Acta. 2010 Sep 16;677(2):156-61 https://www.ncbi.nlm.nih.gov/pubmed/20837182 Abstract Two simple methodologies are compared for the detection of faecal contamination in water using amperometry at gold interdigitated microelectrodes. They rely on the detection of β-galactosidase (β-gal) by redox cycling amperometry of the p-aminophenol

Casals E, Pfaller T, Duschl A, Oostingh GJ, Puntes V. ACS Nano. 2010 Jul 27;4(7):3623-32. https://www.ncbi.nlm.nih.gov/pubmed/20553005 Abstract In this work, we explore the formation of the protein corona after exposure of metallic Au nanoparticles (NPs), with sizes ranging from 4 to 40 nm, to cell culture media containing 10% of fetal bovine serum. Under in

Imaz I, Rubio-Martínez M, García-Fernández L, García F, Ruiz-Molina D, Hernando J, Puntes V, Maspoch D. Chem Commun (Camb). 2010 Jul 14;46(26):4737-9. doi: 10.1039/c003084h. Epub 2010 May 20. https://www.ncbi.nlm.nih.gov/pubmed/20485835 Abstract Micro- and nanoscale coordination polymer particles can be used for encapsulating and delivering drugs. In vitro cancer cell cytotoxicity assays showed that these capsules readily

Linares-Palomino J, Husainy MA, Lai VK, Dickenson JM, Galiñanes M. J Physiol. 2010 Jun 15;588(Pt 12):2173-91. doi: 10.1113/jphysiol.2010.190462. Epub 2010 Apr 19. https://www.ncbi.nlm.nih.gov/pubmed/?term=7.%09Selective+blockade+of+protein+kinase+B+protects+the+rat+and+human+myocardium+against+ischaemic+injury Abstract Protein kinase B (PKB/Akt) plays a critical role in cell survival but the investigation of its involvement has been limited by the lack of specific pharmacological agents. In this study, using

Dopeso H, Mateo-Lozano S, Elez E, Landolfi S, Ramos Pascual FJ, Hernández-Losa J, Mazzolini R, Rodrigues P, Bazzocco S, Carreras MJ, Espín E, Armengol M, Wilson AJ, Mariadason JM, Ramon Y Cajal S, Tabernero J, Schwartz S Jr, Arango D. Clinical Cancer Research. 2010 Apr 15;16(8):2375-82 https://www.ncbi.nlm.nih.gov/pubmed/20371676 Abstract PURPOSE: Irinotecan (CPT11) treatment significantly improves the

Domínguez C, Delgado P, Vilches A, Martín-Gallán P, Ribó M, Santamarina E, Molina C, Corbeto N, Rodríguez-Sureda V, Rosell A, Alvarez-Sabín J, Montaner J Stroke. 2010 Apr;41(4):653-60. https://www.ncbi.nlm.nih.gov/pubmed/?term=20185784 Abstract BACKGROUND AND PURPOSE: Animal models of transient ischemia suggest that oxygen-derived free radicals produced on reperfusion of ischemic brain could constitute the main cause of reperfusion

Isaac Ojea-Jiménez, Francisco M Romero, Neus G Bastús, Victor Puntes J. Phys. Chem. C, 2010, 114 (4), pp 1800–1804 http://pubs.acs.org/doi/abs/10.1021/jp9091305 Abstract The effect of solvent isotopic replacement (H for D) on the size of gold nanoparticles (Au NPs) prepared by sodium citrate reduction has been investigated. With increasing replacement of water by deuterium oxide, smaller

Hellin JL, Bech-Serra JJ, Moctezuma EL, Chocron S, Santin S, Madrid A, Vilalta R, Canals F, Torra R, Meseguer A, Nieto JL. Am J Kidney Dis. 2009 Nov;54(5):871-80. https://www.ncbi.nlm.nih.gov/pubmed/?term=Very+low+molecular+weight+fragments+of+albumin+in+the+plasma+of+patients+with+Focal+Segmental+Glomerulosclerosis Abstract BACKGROUND: Primary focal segmental glomerulosclerosis (FSGS) is a glomerular disease that frequently does not respond to treatment and progresses to kidney failure. FSGS can be

Dopeso H, Mateo S, Mazzolini R, Rodrigues P, Lagares-Tena L, Ceron J, Romero J, Esteves M, Landolfi S, Hernández-Losa J, Castaño J, Wilson AJ, Ramon y Cajal S, Mariadason JM, Schwartz Jr S, Arango D. Cancer Research 2009 Sep 15;69(18):7430-8 https://www.ncbi.nlm.nih.gov/pubmed/19738063 Abstract Colorectal cancer is the second cause of cancer-related death in the western world,

Puigmulé M, López-Hellin J, Suñé G, Tornavaca O, Camaño S, Tejedor A, Meseguer A. Nephrol Dial Transplant. 2009 Sep;24(9):2672-86.   https://www.ncbi.nlm.nih.gov/pubmed/?term=Differential+Proteomic+Analysis+of+Cyclosporine+A-induced+Toxicity+in+Renal+Proximal+Tubule+Cells Abstract BACKGROUND: The use of cyclosporine A (CsA) as a potent immunosuppressant has been limited by its severe nephrotoxic effects. The mechanisms involved are haemodynamic but also related to direct toxic effects of CsA

Barrena R, Casals E, Colón J, Font X, Sánchez A, Puntes V. Chemosphere. 2009 May;75(7):850-7. https://www.ncbi.nlm.nih.gov/pubmed/19264345 Abstract Since society at large became aware of the use of nanomaterials in ever growing quantities in consumer products and their presence in the environment, critical interest in the impact of this emerging technology has grown. The main concern

Comabella M, Domínguez C, Rio J, Martín-Gallán P, Vilches A, Vilarrasa N, Espejo C, Montalban X. Clin Immunol. 2009 May;131(2):216-22. doi: 10.1016/j.clim.2008.12.004. Epub 2009 Jan 26. https://www.ncbi.nlm.nih.gov/pubmed/?term=19176289 Abstract A recent study has shown that chitotriosidase (Chit) may play a role in the pathogenesis of multiple sclerosis (MS). Plasma Chit activity was investigated in 219 untreated

Tornavaca O, Pascual G, Barreiro ML, Grande MT, Carretero A, Riera M, Garcia-Arumi E, Bardaji B, González-Núñez M, Montero MA, López-Novoa JM, Meseguer A. Circulation. 2009 Apr 14;119(14):1908-17. doi: 10.1161/CIRCULATIONAHA.108.808543. Epub 2009 Mar 30. https://www.ncbi.nlm.nih.gov/pubmed/?term=Kidney+Androgen-Regulated+Protein+Transgenic+Mice+Show+Hypertension+and+Renal+Alterations+Mediated+by+Oxidative+Stress. Abstract BACKGROUND: Kidney androgen-regulated protein (KAP), a proximal tubule androgen-regulated gene, codes for a protein of unknown function. METHODS AND

Keng-Leong Ang, Derek Chin, Francisco Leyva, Paul Foley, Chandrashekhar Kubal, Shajil Chalil, Lakshmi Srinivasan, Lizelle Bernhardt, Suzanne Stevens, Lincoln T Shenje and Manuel Galiñanes Nature Clinical Practice Cardiovascular Medicine (2008) 5, 663-670 http://www.nature.com/nrcardio/journal/v5/n10/full/ncpcardio1321.HTML   Abstract Background Studies of the transplantation of autologous bone marrow cells (BMCs) in patients with chronic ischemic heart disease have assessed

Eudald Casals, Socorro Vázquez-Campos, Neus G Bastús, Victor Puntes TrAC Trends in Analytical Chemistry, Volume 27, Issue 8, September 2008, Pages 672–683 http://www.sciencedirect.com/science/article/pii/S0165993608001428 Abstract Biocompatibility, biodistribution, biodegradation, inflammation and interference with cells and normal functioning of organs, among other factors, will determine the toxicity of engineered inorganic nanoparticles and carbon nanostructures, and therefore the extent

Shenje LT, Field LJ, Pritchard CA, Guerin CJ, Rubart M, Soonpaa MH, Ang KL, Galiñanes M. PLoS One. 2008 Apr 16;3(4):e1929. doi: 10.1371/journal.pone.0001929. https://www.ncbi.nlm.nih.gov/pubmed/18414652 Abstract AIMS: Cultured cardiac explants produce a heterogeneous population of cells including a distinctive population of refractile cells described here as small round cardiac explant derived cells (EDCs). The aim of

Cabot A, Puntes VF, Shevchenko E, Yin Y, Balcells L, Marcus MA, Hughes SM, Alivisatos AP. J Am Chem Soc. 2007 Aug 29;129(34):10358-60. Epub 2007 Aug 3. https://www.ncbi.nlm.nih.gov/pubmed/?term=Vacancy+coalescence+during+oxidation+of+iron+nanoparticles Abstract In the present work, we analyze the geometry and composition of the nanostructures obtained from the oxidation of iron nanoparticles. The initial oxidation of iron takes

Davalos V, Dopeso H, Castaño J, Wilson AJ, Vilardell F, Romero-Gimenez J, Espín E, Armengol M, Capella G, Mariadason JM, Aaltonen LA, Schwartz Jr. S, Arango D. Cancer Research, 2006; 66(18):8943-8948 https://www.ncbi.nlm.nih.gov/pubmed/16982731 Abstract The family of receptor tyrosine kinases EPH and their Ephrin ligands regulate cell proliferation, migration, and attachment. An important role in colorectal carcinogenesis is

Crispi F, Domínguez C, Llurba E, Martín-Gallán P, Cabero L, Gratacós E. Am J Obstet Gynecol. 2006 Jul;195(1):201-7. Epub 2006 Mar 20. https://www.ncbi.nlm.nih.gov/pubmed/?term=16545329   Abstract OBJECTIVE: The purpose of this study was to evaluate possible relationships between placental markers and endothelial dysfunction in preeclampsia and intrauterine growth restriction. STUDY DESIGN: A prospective study was conducted

Bartunek J, Dimmeler S, Drexler H, Fernández-Avilés F, Galinanes M, Janssens S, Martin J, Mathur A, Menasche P, Priori S, Strauer B, Tendera M, Wijns W, Zeiher A; task force of the European Society of Cardiology. Eur Heart J. 2006 Jun;27(11):1338-40. Epub 2006 Mar 16. https://www.ncbi.nlm.nih.gov/pubmed/16543252   Abstract A task force has been established by

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S Jr, Esteller M. Nat. Genet., 2006 April;38(5):566-569. http://www.nature.com/ng/journal/v38/n5/full/ng1773.HTML Abstract Disruption of histone acetylation patterns is a common feature of cancer cells, but very

Kogan MJ1, Bastus NG, Amigo R, Grillo-Bosch D, Araya E, Turiel A, Labarta A, Giralt E, Puntes VF. Nano Lett. 2006 Jan;6(1):110-5. Abstract The local heat delivered by metallic nanoparticles selectively attached to their target can be used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this principle to protein

Silvio Carrettin, Patricia Concepción, Avelino Corma, José M López Nieto, Victor F Puntes Angewandte Chemie International Edition 43(19):2538-40 · May 2004   http://onlinelibrary.wiley.com/doi/10.1002/anie.200353570/full Abstract The smaller the better: Depositing gold on nanocrystalline particles of cerium oxide, instead of a regular cerium oxide support, increases the activity of the resulting catalyst by two orders of magnitude for the

Puntes VF, Gorostiza P, Aruguete DM, Bastus NG, Alivisatos AP. Nat Mater. 2004 Apr;3(4):263-8. Epub 2004 Mar 28. https://www.ncbi.nlm.nih.gov/pubmed/?term=Collective+behaviour+in+two-dimensional+cobalt+nanoparticle+assemblies+observed+by+magnetic+force+microscopy Abstract The use of magnetic nanoparticles in the development of ultra-high-density recording media is the subject of intense research. Much of the attention of this research is devoted to the stability of magnetic moments, often neglecting

Victor F. Puntes , Daniela Zanchet , Can K. Erdonmez , and A. Paul Alivisatos  Journal of the American Chemical Society, 2002, 124 (43), pp 12874–12880 http://pubs.acs.org/doi/abs/10.1021/ja027262g Abstract hcp Co disk-shaped nanocrystals were obtained by rapid decomposition of cobalt carbonyl in the presence of linear amines. Other surfactants, in addition to the amines, like phosphine oxides and oleic acid were used to improve size dispersion,

Victor F. Puntes, Kannan M. Krishnan and Paul Alivisatos Applied Physics Letters. 78, 2187 (2001) http://aip.scitation.org/doi/abs/10.1063/1.1362333 ABSTRACT A method of producing high-quality magnetic colloidal dispersions by the rapidpyrolysis of cobalt carbonyl in an inert atmosphere was employed to produce monodispersed, stabilized, defect-free ε-cobalt nanocrystals, with spherical shapes and sizes ranging from 3 to 17 nm. The size distribution and the shape of the nanocrystals were

Victor F. Puntes, Kannan M. Krishnan, A. Paul Alivisatos Science  16 Mar 2001: Vol. 291, Issue 5511, pp. 2115-2117 http://science.sciencemag.org/content/291/5511/2115 Abstract We show that a relatively simple approach for controlling the colloidal synthesis of anisotropic cadmium selenide semiconductor nanorods can be extended to the size-controlled preparation of magnetic cobalt nanorods as well as spherically shaped